Patrick (14-2) saw his 13 fight winning streak snapped against the rough-and-tumble Brian Ebersole at UFC 140 last December. It was the first defeat inside the Octagon for "The Prince," who will try to prove he's still royalty against a very well-rounded fighter.
Which one of these talented welterweights gets it done on fight night?
UFC 149 features a main event title fight between reigning featherweight champion Jose Aldo putting his 145-pound title on the line against the dangerous striking attack of division number one contender Erik Koch.
Other main card match-ups include Antonio Rodrigo Nogueira's return from injury to face off against Cheick Kongo while Michael Bisping tries to get back into the 185-pound title hunt against middleweight "Barbarian" Tim Boetsch.
For more on the promotion's Calgary debut check out our complete UFC 149 event archive right here.