There could be a "huge" change in the line-up for the upcoming UFC 146 main event, scheduled for the MGM Grand Garden Casino in Las Vegas, Nevada on May 26, 2012.

That's because Alistair Overeem, who was expected to challenge UFC Heavyweight Champion Junior dos Santos in the "Sin City" headliner live on pay-per-view (PPV), has yet to be licensed by the Nevada State Athletic Commission (NSAC) after failing his pre-fight drug test.

And Junior dos Santos called it.

Well, sort of. If we run it back to April of 2011, "Cigano," who recently went on record to declare himself "clean," was awestruck by how "huge" his heavyweight counterparts were, including former division champion Brock Lesnar and of course, "Demolition Man," who was wearing 265-pounds of gold under the Strikeforce banner.

Here's what he told UFC Sem Limites about the performance-enhancing drug (PED) abuse in his weight class while hyping his upcoming coaching duties on The Ultimate Fighter (TUF) 13:

"No I've never seen (someone taking performance-enhancing drugs [PEDs]), but I think at Heavyweight that happens a lot for sure. When you see people like Alistair Overeem, Brock Lesnar, look at the size of those guys, they're really big. As Mario (Yamasaki) said, a lot of people use them but a lot of people don't. I'm someone who has never used (PEDs), I think I came in the good phase of MMA and I've never used them."

There are no secrets in mixed martial arts (MMA) and when "The Reem" got word of the Brazilian's "nice comment," he threatened to exact revenge at a later date.

See what he told the MMA Fight Corner after the jump.

"Cain Velasquez (is who I want to fight the most). And why? Because he is the UFC champion, and believe you me when the tournament is over, I'll be coming for him. And after I'm done with him, we're gonna go after dos Santos for his nice comment."

The Overeem War Wagon lost one of its wheels in the middle of the Strikeforce Heavyweight Grand Prix. After a lackluster win over Fabricio Werdum last June, the Dutch striker balked at ZUFFA's proposed timeline for his next fight, then withdrew from the tournament altogether with a mysterious toe injury.

It was not the first time Overeem bailed on a stateside fight, either, blowing off a potential showdown with Brett Rogers in 2009 because of a cut sustained during a bar fight in Amsterdam.

And let's not forget that whole drug test fiasco that resulted in a conditional license prior to his participation at UFC 141 last December.

In short, it's been a rocky road for Overeem and producing a drug test result with a staggering testosterone-to-epitestosterone (T/E) ratio of 14:1 only serves to reinforce Junior's previous suspicions.

All that stands in the way of pitchforks and torches is Alistair's "B" sample, but in order to do that, he must first come forward and ask to have it tested.

Overeem ... Overeem ... Bueller ...