To be frank, there's never been a better time to lay down some cheddar on Mir.

That's because the former UFC Heavyweight Champion, who's been on a long and arduous journey in pursuit of the 265-pound crown, is a +325 underdog in his fight against Cain Velasquez, booked for UFC 146 on May 26, 2012, at the MGM Grand Garden Arena in Las Vegas, Nevada.

Velasquez is the -500 favorite, according to our fiscal friends at Best Fight Odds.

Despite a three-fight winning streak, one that culminated in a bone-breaking win over Antonio Rodrigo Nogueira at UFC 140 last December, Mir (16-5) was lit up on his feet by the aging Brazilian prior to the submission finish. Velasquez, widely-recognized as the division's finest wrestler, also has knockout power and never-ending cardio.

But -500?

Once considered unstoppable, "Brown Pride" was brown-bagged and eaten for lunch by a hungry Brazilian bomb-dropper named Junior dos Santos, whose two shots to the dome ended their UFC on FOX headliner in just over a minute.

The poor performance by Velasquez (9-1), which may have been overly-criticized considering he only had 64 seconds to strut his stuff, was attributed to his long layoff for shoulder surgery, as well as a bum knee sustained in training camp.

But was the loss to "Cigano" a bump in the road? Or the beginning of the end?

We know what the oddsmakers think. How about you? Let's get some initial reactions to the opening lines. Cain getting too much respect? Or Frank not getting enough?

More on their titanic tilt right here.