After more than four years, he'll try to do it again.
This time the roles will be reversed, as "The California Kid" is not only the challenger, he's also the +115 underdog against "The Dominator's" slight edge as -135 betting favorite.
So far, he's seen nothing but success, winning both fights in his new weight class: a submission victory over Japanese stalwart Takeya Mizugaki (WEC 52) and a decision win over the venerable Eddie Wineland (UFC 128).
But is that enough to convince you he's championship material?
To his credit, Cruz has done nothing but "Dominate" since starting his young career back in early 2005.
The Alliance MMA product has been on a stellar run, winning 17 of his 18 career contests. The lone blemish? To none other than Faber himself, at the aforementioned WEC event back in 2007.
These two have had a grudge building in the media for a while now, with Faber calling Cruz a "d-bag" and Dominick repeatedly stating he would love to avenge his only career loss.
Can he pass perhaps his biggest test to date?
Dominick Cruz (-135) vs. Urijah Faber (+115) at UFC 132.
Who ya' got?