The two will battle on Nov. 19, 2011, at the HP Pavilion in San Jose, California, for a spot in the pecking order in what has become a tight division title race. "Hendo" is a slight favorite heading into "Silicon Valley," sitting pretty at -130 while "Shogun" is listed as the +100 underdog.
Henderson's stock is as high as it has ever been, following violent finishes over his last three opponents, including a high-profile stoppage over famed Russian heavyweight Fedor Emelianenko back in July.
The former Olympian hasn't seen the inside of the Octagon since nearly killing Michael Bisping at UFC 100 a little over two years ago.
Now he's back and one division heavier.
Rua has struggled to put together s streak of consistent performances since his UFC debut back in 2007.
His most recent win came at UFC 134, when he smashed Forrest Griffin to avenge his debut loss and erase the memories of the shellacking he took when surrendering the 205-pound title to Jon Jones earlier this year.
A win over Henderson could make a strong argument for a "Bones" rematch -- or at least an title eliminator fight opposite Rashad Evans.